Second traditional assessment, the Clinical Global Impression CGI reflects the impression of skilled observer, fully familiar with the manifestations of schizophrenia, about the overall clinical state of the patient. Drink plenty of fluids, dress lightly, and stay in cool air-conditioned areas when the weather is hot. Quetiapine adversely affected mating and fertility in female Sprague-Dawley rats at an oral dose of 50 mg kg, or. Patients who develop NMS may have high fevers, muscle rigidity, altered mental status, irregular pulse or blood pressure, rapid heart rate, excessive sweating, and heart arrhythmias. In vitro, quetiapine did not affect the binding of warfarin or diazepam to human serum albumin. Schizophrenia The efficacy of SEROQUEL in the treatment of rekkefolge quetiapine uten resept schizophrenia was established in short-term 6-week controlled trials of inpatients with schizophrenia who met DSM III-R criteria for schizophrenia.