Consumer continued SIDE EFFECTS: You may experience dizziness, lightheadedness, blurred vision, stomach upset, or heartburn as your body adjusts to the medication. Two of the placebo-controlled trials identified above and additional placebo-controlled studies examined the antihypertensive effects of irbesartan and hydrochlorothiazide in combination. Non-steroidal Anti-inflammatory Drugs: in some patients, the administration of non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Irbesartan-hydrochlorothiazide was negative in tests for induction of chromosomal aberrations in vitro human lymphocyte in vivo mouse letakas avalide brand generic micronucleus study. The primary circulating metabolite is the inactive irbesartan glucuronide conjugate approximately. Geriatric Use Of 1694 patients receiving AVALIDE in controlled clinical studies of hypertension, 264 15.