Also watch out for sudden or severe changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and amitriptyline odavad ei liikmelisuse hyperactive, or not being able to sleep. RxList does not provide medical advice, diagnosis or treatment. Ask your health care provider any questions you may have about how to use Amitriptyline. Amitryptiline also has what are called anticholinergic effects which requires some explanation. The dosage may then be adjusted cautiously to produce an adequate response. Recent research suggests inflammation in the nervous system is major causative factor for this condition.